Genes Unlock New Treatments for Deadly Melanoma

Released on: October 25, 2007, 2:26 pm

Press Release Author: Society for Melanoma Research

Industry: Healthcare

Press Release Summary: Scientific Meeting Highlights New Therapies and Diagnostics,
Holding Promise for Melanoma Patients

Press Release Body: NEW YORK - Record-high registration at the upcoming 2007
International Melanoma Congress signals new promise and hope in treating a disease
that has long held a dismal prognosis for those in the advanced stages. Caught
early, melanoma is one of the easiest cancers to treat, but caught late, melanoma is
one of the most incurable and deadly.

This year's Congress highlights the growing understanding about the underlying
genetic mutations that cause melanoma. "With each genetic mutation we successfully
identify, it opens up yet another door to a new therapy," says Ze'ev Ronai, Ph.D.,
organizer of this year's Congress and Program Director at the Burnham Institute for
Medical Research. "What's clear is that a broad-spectrum approach to treating
advanced melanoma is rapidly being replaced by targeted and likely personalized
therapies."

The median life expectancy for those with advanced melanoma is nine months and
existing therapies have not improved survival in more than a decade. Approximately
five years ago, the research community began unlocking the underlying genetic
malfunctions that occur in cells, causing melanoma. Today, researchers are
beginning to correlate those discoveries to therapies that may have a meaningful
impact on the survival of patients.

"We're starting to understand that melanoma is actually many different diseases and
that there is not one easy magic bullet that we're going to find," says Lynn
Schuchter, M.D., Professor of Medicine at the Abramson Cancer Center of University
of Pennsylvania. "But there is great excitement not only for the drugs in
development, but also from the fact that much of the basic science being done has
implications for patients now. In many cases we don't have to wait for a new drug
to be developed. Drugs that are already on the market are being used to slow down
disease progression."

Highlights of the Congress includes:
- research uncovering the usefulness of an existing drug
- promising results of Stage II and Stage III clinical trials
- a better diagnostic tool soon to be available
- basic research findings that will serve as a platform for future therapies.

The Society for Melanoma Research meeting also marks a change in the Society's main
scientific publication. Pigment Cell Research will become Pigment Cell and Melanoma
Research to underscore the rapidly expanding potential in melanoma research, and
will serve as a focal point for the international research community in discussing
advances in field. A preview issue produced for the Congress will be dedicated to
melanoma research. The renamed journal will be officially launched in January 2008.


About the Society for Melanoma Research
The Society for Melanoma Research (SMR) is an all-volunteer group of scientists
working to find the mechanisms responsible for melanoma and, consequently, new
therapies for this cancer. SMR contributes to advances in melanoma research by
bringing together researchers in a non-competitive way to unite the scientific
community. The Society has commissioned the Roadmap for Melanoma which outlines the
key targets for research and therapy that need to be addressed by 2010.
www.melanomacongress07.net

# # #

NOTE TO REPORTERS: A press room will be available to working reporters. To
register for the meeting, or to obtain an embargoed research preview, contact Berna
Diehl at berna@jonespa.com.



Web Site: http://www.melanomacongress07.net

Contact Details: Contact: Berna Diehl, Jones Public Affairs, 703-966-3602,
berna@jonespa.com

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